c-Kit W557_K558del-D816V/BaF3
CBP73285
詢 價(jià)
留 言
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Background | |
| KIT W557_K558del results in the deletion of 2 amino acids in the juxtamembrane domain (exon 11) of the Kit protein from amino acids 557 to 558 . W557_K558del results in constitutive activation of Kit and increased Erk phosphorylation, and leads to increased invasiveness and expression of ETV1 in cell culture . | |
| II. Introduction | |
|
Cell Line Name： |
c-Kit W557_K558del-D816V/BaF3 |
|
Host Cell: |
BA/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
|
Application: |
Anti-proliferation assay and PD assay |
|
Freeze Medium: |
90% FBS+10% DMSO |
|
Complete Culture Medium: |
RPMI-1640+10%FBS |
|
Mycoplasma Status: |
Negative |
| III. Representative Data | |
|
1. WB of c-Kit W557_K558del-D816V/BaF3
|
|
|
2. Sanger of c-Kit W557_K558del-D816V/BaF3
Figure 2. c-Kit W557_K558del-T670I/BaF3 D816V
Figure 3. c-Kit W557_K558del-T670I/BaF3 W557_K558del |
|
|
3. Anti-proliferation assay
Figure 4. CTG Proliferation Assay of BaF3 c-KIT W557_ K558del/D816V (C5). |
|
|
|
|
